HRC Fertility is a pioneer in Needle-free IVF, offering a compassionate alternative for those apprehensive about needles. Our team expertly utilizes this innovative technique, using a catheter instead of traditional needles to make the IVF process more comfortable and accessible. Our commitment to personalized care ensures you receive the support you need on your fertility journey.
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Research indicates that approximately two-thirds of fertility patients experience needle anxiety. Ovarian stimulation, essential for egg freezing or IVF, typically involves daily self-injections, ranging from two to four per day, depending on the medication protocol.
While this process is generally seen as a necessary step towards the ultimate goal of achieving a successful pregnancy, the emotional and physical toll it may take for some patients can be substantial, and stress and anxiety associated with frequent needle injections can lead to treatment drop-outs or delays.
Dr. Rachel Mandelbaum of HRC Fertility has introduced an innovative solution: “Needle-Free IVF.”
Needle-Free IVF utilizes a subcutaneous catheter system, similar to a continuous glucose monitor, to administer medications without traditional needle injections.
The FDA-approved Neria Guard, generally used for other medical purposes, has been adapted off-label for IVF, representing a significant advancement in fertility care. As a pioneer in reproductive medicine, Dr. Mandelbaum was motivated to develop this approach after observing the challenges patients faced with needle injections during IVF.
After she saw how insulin pumps transformed the lives of patients with type I diabetes, she was inspired to explore a similar technology for fertility treatments. Dr. Mandelbaum conducted a clinical study, completed in 2023 and now published in Fertility & Sterility, that demonstrated excellent outcomes for participants undergoing IVF or egg freezing, and high patient satisfaction. All those who had previously undergone IVF with needle injections preferred the Needle-Free approach.
In response to overwhelmingly positive feedback, needle-free IVF is now available in Beverly Hills, West Los Angeles, Pasadena, and at multiple HRC practice locations.


During Needle-Free IVF, a subcutaneous catheter—similar to those used for continuous medication delivery in other medical contexts—is placed under the skin. This device, adapted from the FDA-approved Neria Guard system, allows for continuous and precise delivery of fertility medications. Patients can manage their treatment with ease, eliminating the need for multiple daily needle injections.
Needle-Free IVF augments the fertility experience by eliminating needle anxiety and the stress associated with daily injections.
This innovative approach improves treatment adherence by offering a more manageable protocol, ensuring patients stay on track toward their parenthood goals. With continuous medication delivery through a subcutaneous catheter system, patients experience unparalleled convenience and comfort. Clinical studies validate that Needle-Free IVF provides outcomes as successful as traditional methods, making it a transformative option for those seeking a stress-free fertility journey.
Needle-Free IVF is ideal for patients who:

The process uses a subcutaneous catheter system to deliver medications without the need for daily injections, offering a pain-free and stress-free experience.
The subcutaneous catheter system, Neria Guard, is FDA-approved for other medical uses and has been adapted off-label for IVF under Dr. Mandelbaum’s expertise.
Yes, clinical trials have shown that Needle-Free IVF provides outcomes comparable to traditional injection-based protocols.
This innovative treatment is currently offered at several HRC Fertility locations, including Pasadena, Beverly Hills, and West Los Angeles.